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Dr. Gerald Spaeth - Leishield MATI

Dr. Gerald Spaeth holds a Research Director and Chair of Excellence position at the Institut Pasteur in Paris, where he directs the Unit ‘Parasitologie moléculaire et Signalisation’ and the Department ‘Parasites and Insect Vectors’. His research investigates Leishmania/host interaction applying integrative approaches to study (i) parasite adaptive differentiation and evolution during intracellular infection, (ii) modulation of the host cell phenotype by the release of parasite signaling proteins, and (iii) impact of such parasite trans-signaling on the host cell immune-competence. Each of these research axes has a strong translational component dedicated to biomarker, drug target or compound discovery, which are at the core of the various coordination actions conducted by Dr. Spaeth on the national and international levels. Currently, he co-directs an International Mixed Unit (IMU) with a partner team at IP Shanghai, and animates the LeishRIIP platform ( that represents the Leishmania research community of the Institut Pasteur International Network (IPIN). Since 2014 he is the scientific director of the IPIN-sponsored LeiSHield project that applies an integrative approach to understand clinical Leishmania infection in the field and has been recently awarded €1,7 M from the EU H2020-MSCA-RISE program (

His unit : Molecular Parasitology and Signaling